NCT07601048
A Trial of HRS-7058 in Advanced or Metastatic Non-Small Cell Lung Cancer Patients Who Have Failed Standard Treatment
Not Yet Recruiting · Phase 3 · Shandong Suncadia Medicine Co., Ltd. · registry updated 2026-05-22
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
The study is being conducted to evaluate the efficacy, and safety of HRS-7058 in KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer Patients Who Have Failed Standard Treatment
Inclusion
- Age 18 years old to 75 years old ( including both ends ), regardless of gender ;
- Subjects with histologically or cytologically confirmed locally advanced or metastatic non-small cell lung cancer ;
- Histological specimens confirmed the presence of KRAS G12 C mutation ;
- Participants who have failed at least one line of systemic anti-tumor treatment in the locally advanced or metastatic stage. Previous systemic anti-tumor treatment should include : platinum-containing double-agent chemotherapy and immune checkpoint inhibitor therapy ( synchronous or sequential, except that the researchers determine that it is not suitable for immune checkpoint inhibitors or chemotherapy ) ;
- At least one measurable lesion conforming to the definition of RECIST v1.1 standard ;
- ECOG physical score 0-1 points ;
Exclusion
- Subjects with active central nervous system ( CNS ) metastasis ;
- Other malignant tumors occurred within 5 years before the first administration, except for fully treated cervical carcinoma in situ, basal cell or squamous cell skin cancer, local prostate cancer after radical resection, ductal carcinoma in situ after radical resection, and papillary thyroid carcinoma after radical resection.
- Having undergone major surgery or significant trauma within 4 weeks prior to the first use of the study drug ;
- Subjects with a history of interstitial pneumonia or suspected interstitial pneumonia by imaging examination during screening ; or other lung diseases that seriously affect lung function ;
- Have serious cardiovascular and cerebrovascular diseases
- Severe infection occurred within 4 weeks before the first administration.