NCT07412028
Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With "Classic" Polycystic Ovary Syndrome (PCOS)
Recruiting · Not Applicable · Assistance Publique - Hôpitaux de Paris · registry updated 2026-08-10
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
Diagnostic case-control study (1 case for 2 controls). Inclusion of patients with severe insulin resistance syndrome of genetic origin, then inclusion of controls: patients examined for PCOS in day hospital with matching age (+/- 5 years) and Body mass index (+/- 5kg/m2).
Inclusion
- Women aged ≥ 18 years and \< 45 years ;
- Discontinuation of estrogen-progestin therapyfor at least 3 months ;
- Signed informed consent ;
- Social security affiliation.
- Case (n=25):
- \- Patient with a lipodystrophic syndrome due to a known pathogenic variant of the LMNA gene.
Exclusion
- \- Severe renal insufficiency (GFR \< 30 ml/min) ;
- Hepato-cellular insufficiency (TP \< 50%) ;
- Taking corticosteroids or antiretrovirals ;
- Menopausal women ;
- Taking estrogen-progestin therapy;
- Diabetic patients on insulin : type 1 diabetes or pancreatectomised patients