NCT07226284
Effects of Vagal Nerve Stimulation on Leg Muscle Activity and Posture in Parkinson's Disease
Recruiting · Not Applicable · University of Minnesota · registry updated 2026-02-13
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
This study is designed to better understand the mechanisms contributing to impaired activation of leg muscles in people with Parkinson's disease (PD) and to test if stimulation of a nerve at the neck can improve muscle activation, walking and balance.
Inclusion
- Diagnosis of idiopathic Parkinson's disease,
- On stable medication for the preceding month and anticipated over the next 3 months,
- Able to ambulate without the use of an assistive device for more than 50 meters.
- Control Cohort:
- Age (± 3 years) and sex distribution matched to the PD cohort,
- Able to ambulate without the use of an assistive device for more than 50 meters.
Exclusion
- Failure to demonstrate capacity to consent (based on UBACC and/or MacArthur-CR),
- History of significant neurological disorder (besides PD in the PD group),
- History of stroke, traumatic brain injury, intracranial aneurysm, intracranial hemorrhage, brain tumor or atypical parkinsonian disorder,
- Severe orthopedic or other related musculoskeletal pathology that has significant adverse effects on gait,
- Women who are pregnant or may be pregnant,
- Insufficient comprehension of the English language,