NCT06835426
High-resolution PET-CT Specimen Imaging for the Perioperative Visualization of Resection Margins
Recruiting · Not Applicable · Algemeen Ziekenhuis Maria Middelares · registry updated 2025-02-19
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
These are patients in whom a benign or malignant tumor was recorded requiring surgery. During that surgery, the surgeon will cut away the tumor as part of the treatment of the disease. In this process, it is important that the tumor is removed correctly and completely. To verify that the correct tissue was completely removed, the tissue is examined microscopically. However, a microscopic analysis takes a relatively long time and the result is not known until a few days after the surgery is completed. If that microscopic analysis should eventually reveal that the tumor was not completely removed, additional treatment is usually necessary. An assessment of the excised tissue during surgery would allow additional tissue to be excised in the same operation if necessary. Thus, in this way, additional treatments can also be avoided. This could lead to shorter treatment time and less emotional strain for the patient, as well as lower costs. To date, however, there are no effective techniques to do this. PositronEmissionTomography (PET) imaging can be used to image the tumor that needs to be excised. To do this, a tracer must be administered through the blood before the operation....
Inclusion
- able to understand treatment protocol and informed consent form
- estimated by the investigator to be compliant for study participation
- \. Fulfilling all group-specific inclusion criteria:
- confirmed breast cancer with an indication to undergo breast conserving surgery
- confirmed prostate cancer with an indication to undergo resective surgeryprostatectomy;
- confirmed thyroid lesion with an indication to undergo resective surgery;
Exclusion
- general or local contra-indications for resective surgery;
- in case of FDG-based PET tracers: a blood glucose level over 200 mg/dL on the day of surgery;
- pregnancy or lactation;
- participation in other clinical studies with a radiation exposure of more than 1 mSv in the past year.