NCT06650969
China Diabetes Cognitive Dysfunction Early Diagnosis and Intervention Study (China-DECODE Study)
Recruiting · Not specified · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · registry updated 2024-10-21
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
Type 2 diabetes (T2D) and dementia are both diseases with increasing incidence and prevalence globally, leading to substantial economic burdens for families and society. Notably, diabetes significantly increases the risk of cognitive dysfunction, which is classified into preclinical stage, mild cognitive impairment and dementia based on the disease severity. Cognitive dysfunction is a critical contributor to disability and mortality in elderly diabetes patients. Early diagnosis and intervention are crucial for delaying disease progression, enhancing treatment efficacy, and mitigating the impact of dementia. Currently, research and clinical management of cognitive dysfunction in individuals with diabetes are in their infancy, characterized by limitations such as single-center studies, limited sample sizes, inconsistent diagnostic criteria, and insufficient data sharing. Consequently, clinical diagnosis and treatment strategies are underdeveloped, medical staff's related knowledge is lacking, and potential therapeutic targets remain unexplored....
Inclusion
- Age ≥45 years;
- Type 2 diabetes diagnosed according to the American Diabetes Association criteria;
- Willingness and ability to complete systematic neuropsychological tests;
- Understanding of the research procedures and methods, potential benefits and risks of the trial, and sign written informed consent.
Exclusion
- Fewer than 6 years of education;
- Left-handedness;
- Acute metabolic complications such as diabetic ketoacidosis, hyperglycaemic hyperosmolar state and hypoglycaemic coma within the previous 3 months;
- History or presence of neurological or psychiatric disorders;
- Presence of hypothyroidism;
- History of malignancy, or severe kidney or liver dysfunction.