NCT06343558
Gait and Balance Impairment in Rare and Very Rare Neurological Diseases
Recruiting · Not specified · Istituto Auxologico Italiano · registry updated 2025-08-03
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
Rare and very rare neurological diseases primarily or exclusively affect the nervous system with a prevalence of \< 5 out of 10'000 and 100'000 people, respectively. Besides these, there are undiagnosed neurological diseases: neurological conditions without a diagnosis after completing a full diagnostic examination. Rare, very rare, and undiagnosed neurological diseases are complicated and progressive and often cause variegated motor signs, impairments, and syndromes. Balance and gait are frequently affected in these conditions, already at the clinical examination. These balance and gait impairments limit activities and cause an increased risk of falling. Falls can eventually result in injuries, even severe. There are only a few studies about these diseases, likely because of their rarity. Hence, the clinical presentation and the course of rare and very rare diseases are poorly known or even unknown. Essential information for these conditions' diagnosis, prognosis, treatment and rehabilitation is missing....
Inclusion
- Multiple sclerosis, Parkinson's disease, peripheral neuropathy of the lower limbs or rare or ultrarare neurological disease (e.g. la Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome - CANVAS, ORPHAcode: 504476; Wilson's disease, ORPHAcode: 905)
- undiagnosed neurological disease, i.e. a neurological disease that remains unknown after a full diagnostic assessment;
- age \> 18 years;
- ability to stand upright with no assistance and no assistive device for \> 30 seconds;
- ability to walk without assistance and with no assistive device for \> 50 m;
- ability to give their informed consent.
Exclusion
- pregnancy or breastfeeding
- any other medical conditions affecting by itself balance and gait (e.g. lower limb amputation, hemiparesis due to a stroke)
- major orthopaedic surgery (e.g. hip or knee replacement).